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Viagra (Sildenafil) is a potent and selective inhibitor of cGMP specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum. When taking nitric oxide donors, organic nitrites and nitrates, such as glyceryl trinitrate (nitroglycerin), sodium nitroprusside, amyl nitrite you should not take cheap viagra. The molecular structure of sildenafil is similar to that of cGMP and acts as a competitive binding agent of PDE5 in the corpus cavernosum, resulting in more cGMP and better erections. Without sexual stimulation, and therefore lack of activation of the NO/cGMP system, sildenafil should not cause an erection. Viagra (Sildenafil) was synthesized by a group of pharmaceutical chemists working at Pfizer's Sandwich, Kent research facility in England. It was initially studied for use in hypertension (high blood pressure) and angina pectoris (a form of ischaemic cardiovascular disease). Phase I clinical trials under the direction of Ian Osterloh suggested that the drug had little effect on angina, but that it could induce marked penile erections. Pfizer therefore decided to market it for erectile dysfunction, rather than for angina. Occasional erectile dysfunction is a common problem, particularly as men age. Medication won't make you feel like you're 20 again, but it can help you achieve satisfying sexual relations more often. The drug was patented in 1996, approved for use in erectile dysfunction by the Food and Drug Administration on March 27, 1998, becoming the first pill approved to treat erectile dysfunction in the United States, and offered for sale in the United States later that year. It soon became a great success: annual sales of Viagra in the period 1999?2001 exceeded $1 billion. In February 2007, it was announced that Boots the Chemist would trial over the counter sales of Viagra in stores in Manchester, England. Men aged between 30 and 65 would be eligible to buy four tablets. cheap Viagra (Sildenafil) is metabolised by hepatic enzymes and excreted by both the liver and kidneys. Erections occur when there is increased blood flow to the penis. Viagra increases blood flow to the penis, so that when a man is sexually aroused, he can have an erection. When the sexual encounter is over, his erection goes away. If taken with a high-fat meal, there may be a delay in absorption of cheap Viagra (sildenafil) and the peak effect might be reduced slightly as the plasma concentration will be lowered. Under the influence of nitric oxide, these vessels expand and stay dilated. Increased blood flow makes erectile tissue swell and compress the veins that carry blood out of the penis, resulting in a full erection. Viagra should be taken as needed about 1 hour before sexual activity. However, Viagra can be taken anytime from 4 hours to 30 minutes before sexual activity. Cheap Viagra (Sildenafil) is used to treat erectile dysfunction (impotence) and for the treatment of pulmonary arterial hypertension. Symptoms of a cheap viagra overdose are not known, but are likely to include chest pain, dizziness, an irregular heartbeat, and swelling of the ankles or legs, but this is not a general but a particular case. Viagra should not be used by people with sexual intercourse is inadvisable due to cardiovascular risk factors with Severe hepatic impairment (decreased liver function) or hypotension (low blood pressure). If you are taking alpha-blocker therapy, you should not take a dose of greater than 25 mg of Viagra at the same time (within 4 hours) as your dose of alpha-blocker. The name recognition of Viagra? is so good that nearly every adult in America has heard of the drug and can tell you what it does. Viagra? causes a man who is sexually stimulated to get an erection. Maintaining an erection is just as important as getting one. VIAGRA can help with both. This can lead to a more satisfying sexual experience with your partner. Cheap Viagra is a prescription drug used to treat erection difficulties, such as erectile dysfunction. Viagra is used as needed, so you are not likely to miss a dose. If you miss a dose of Viagra, take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose. Since its launch in the United States in March 1998 it has become the best selling drug ever. Cheap Viagra prevents the breakdown of nitric oxide, a chemical messenger that promotes relaxation and opening of the blood vessels that supply erectile tissue in the penis. You may be recommended the lowest dose (25 mg) of Viagra if you are older than age 65, or have serious liver or kidney problems, or you are taking protease inhibitors. Cheap Viagra is rapidly absorbed. Maximum observed plasma concentrations are reached within 30 to 120 minutes (median 60 minutes) of oral dosing in the fasted state. When sildenafil is taken with a high fat meal, the rate of absorption is reduced, with an average delay in the time to maximal concentration of 1 hour. It has been estimated that impotence affects 140 million men worldwide. Over half of all men with impotence are thought to have some physical (medical) cause. The remainder are believed to have psychogenic causes of impotence. Medical causes of impotence include diabetes and circulatory, neurological or urological conditions. Do not take Viagra if you are taking any nitrate-based drug, including nitroglycerin patches (Nitro-Dur, Transderm-Nitro), nitroglycerin ointment (Nitro-Bid, Nitrol), nitroglycerin pills (Nitro-Bid, Nitrostat), and isosorbide pills (Dilatrate-SR, Isordil, Sorbitrate). Combining Viagra with these drugs can cause a severe drop in blood pressure. Cheap Viagra may help you with your erectile problem, it has already been used by milions of people all around the world. Viagra is a blue, film-coated, rounded, diamond-shaped tablets that comes in 25, 50, and 100 mg tablets for treating impotence. Revatio comes in a 20 mg tablet and is used for treating pulmonary arterial hypertension. Keep Viagra in its original container. Store at 25 degrees C (77 degrees F);